Antivirals against polio and other enteroviruses

EUVIRNA ESR-11

Project description
The aim of this project is to study the particular characteristics and to unravel the molecular mechanism of action of novel inhibitors of the replication of picornaviruses (genus enterovirus) that have recently been discovered in our laboratory. The development of inhibitors of enterovirus replication is of utmost importance. Despite intensive vaccination campaigns, the poliovirus is still not eradicated. It is now widely accepted that antivirals will be needed to aid in the late stages of the polio endgame and in the post-polio era. Besides polio, many other enteroviruses cause a wide spectrum of diseases in man (aseptic meningitis; viral myocarditis, respiratory tract infections); there is no vaccine nor specific therapy available.

Host institute
Virology and Experimental Chemotherapy, Rega Institute,
Department of Microbiology and Immunology Faculty of Medicine - K.U. Leuven
Belgium
Supervisor: Prof. Johan Neyts

This position has been filled.