Mode of action of inhibitors of enterovirus replication


Project description
Enteroviruses are highly prevalent and important human pathogens. This group includes among others, poliovirus (cause of paralytic poliomyelitis), coxsackievirus (major cause of aseptic meningitis and viral myocarditis), human rhinovirus (cause of respiratory tract infections and asthma exacerbations), and enterovirus 71 (cause of large outbreaks in Asia associated with severe neurological sequelae). Thus far, no potent antiviral drugs are available for treatment of enterovirus infections. Recently, we have identified a number of small molecules that inhibit enterovirus replication. In this project, the mode of action of these inhibitors will be investigated in detail.

Host institute
Utrecht University, Utrecht, The Netherlands
Department of Infectious Diseases & Immunology, division of Virology
Supervisor: Prof. dr. Frank van Kuppeveld

Position filled