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Scientific publications by fellows of the network

ESR-1Utrecht University Cristina M. Dorobantu , Hilde M. van der Schaar , Lauren A. Ford , Jeroen R.P.M. Strating , Rachel Ulferts , Ying Fang , George A Belov and F.J.M van Kuppeveld. Recruitment of PI4KIIIβ to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1., J Virol. 2014 Mar;88(5):2725-36 doi:10.1128/JVI.03650-13JVI.03650-13
ESR-3Aix Marseille UniversitéBouvet M, Imbert I, Subissi L, Gluais L, Canard B, Decroly, RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex, Proc Natl Acad Sci U S A. 2012 109(24):9372-7. doi: 10.1073/pnas.1201130109
ESR-3Aix Marseille Université Subissi L ., Decroly E., Gluais L. Bouvet M., Canard B., Imbert I., "Les enzymes de la réplication/transcription chez les Coronavirus" English : Coronavirus replication/transcription enzymes, accepted in french journal Virologie
ESR-3Aix Marseille Université Subissi L ., Imbert I, Ferron F, Collet A, Coutard B, Decroly E, Canard B., SARS-CoV ORF1b-encoded nonstructural proteins 12-16; Replicative enzymes as antiviral targets., Antiviral Res. 2014 Jan;101:122-30. doi: 10.1016/j.antiviral.2013.11.006
ESR-4Aix Marseille UniversitéBignon C, Li C , Lichière J, Canard B, Coutard B., Improving the soluble expression of recombinant proteins by randomly shuffling 5' and 3' coding-sequence ends., Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2580-2. doi: 10.1107/S0907444913018751
ESR-4Aix Marseille UniversitéBruno Coutard, Etienne Decroly, Changqing Li , Andrew Sharff, Julien Lescar, Gérard Bricogne and Karine Barral. Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery. Antiviral Res. 2014 Jun;106:61-70. doi: 10.1016/j.antiviral.2014.03.013
ESR-5University Hospital of HeidelbergChelsea M. Byrd, Dongcheng Dai, Douglas W. Grosenbach, Aklile Berhanu, Kevin F. Jones, Kara B. Cardwell, Christine Schneider, Kristin A. Wineinger, Jessica M. Page, Chris Harver, Eric Stavale, Shanthakumar Tyavanagimatt, Melialani A. Stone, Ralf Bartenschlager, Pietro Scaturro, Dennis E. Hruby, Robert Jordan “A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein”. Antimicrobial Agents and Chemotherapy, 2013, 57(1):15. doi: 10.1128/AAC.01429-12
ESR-9Leiden University Medical CenterZengqin Deng, Kathleen C. Lehmann , Xiaorong Li, Chong Feng, Guoqiang Wang, Qi Zhang, Xiaoxuan Qi, Lin Yu, Xingliang Zhang, Wenhai Feng, Wei Wu, Peng Gong, Ye Tao, Clara C. Posthuma, Eric J. Snijder, Alexander E. Gorbalenya, and Zhongzhou Chen; Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Res. 2014 Mar;42(5):3464-77. doi: 10.1093/nar/gkt1310
ESR-10Leiden University Medical CenterDavid Olagnier, Florine Scholte, Cindy Chiang, Irina Albulescu , Carmen Nichols, Zhong He, Rongtuan Lin, Eric Snijder, Martijn van Hemert, and John Hiscott, Inhibition of dengue and chikungunya virus infection by RIG-I-mediated type I IFN-independent stimulation of the innate antiviral response, J Virol. 2014 Apr;88(8):4180-94 doi: 10.1128/JVI.03114-13
ESR-12Catholic University of LeuvenChatelain G, Debing Y, De Burghgraeve T, Zmurko J , Saudi M, Rozenski J, Neyts J, Van Aerschot A; In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues. Eur J Med Chem 2013. ;65:249-55. doi: 10.1016/j.ejmech.2013.04.034
ESR-12Catholic University of LeuvenSaudi M, Zmurko J , Kaptein S, Rozenski J, Neyts J, Van Aerschot A., In search of Flavivirus inhibitors part 2: tritylated, diphenylmethylated and other alkylated nucleoside analogues. Eur J Med Chem. 2014 Apr 9;76:98-109. doi: 10.1016/j.ejmech.2014.02.011
ESR-17 and ER-3Okapi Sciences NV & Catholic University of LeuvenLefebvre DJ, De Vleeschauwer AR, Goris N, Kollanur D , Billiet A, Murao LE, Neyts J and De Clercq K, Proof-of-concept for the inhibition of foot-and-mouth disease virus replication by the antiviral drug 2’-C-methylcytidine in severe combined immunodeficient mice. Transboundary and Emerging Diseases. 2013 Mar 11. doi: 10.1111/tbed.12069
ESR-17 1 and 2 & ER-3Okapi Sciences NV & Catholic University of Leuven Osiceanu AM, Murao LE, Kollanur D, Swinnen J, De Vleeschauwer AR, Lefebvre DJ, De Clercq K, Neyts J and Goris N, In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease virus outbreaks. Antiviral Research, Antiviral Res. 2014 May;105:59-63. doi: 10.1016/j.antiviral.2014.02.009
ER-2Utrecht University & Catholic University of Leuven Thibaut HJ , van der Schaar HM, Lanke KH, Verbeken E, Andrews M, Leyssen P, Neyts J, vanKuppeveld FJ., Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for PI4KIIIβ., J Virol. 2014 Mar;88(5):3048-51. doi: 10.1128/JVI.03177-13
ER-2Utrecht University & Catholic University of Leuvenvan der Schaar HM, Leyssen P, Thibaut HJ , de Palma A, van der Linden L, Lanke KH, Lacroix C, Verbeken E, Conrath K, Macleod AM, Mitchell DR, Palmer NJ, van de Poël H, Andrews M, Neyts J, van Kuppeveld FJA novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81 doi: 10.1128/AAC.01175-13
ER-2Utrecht University & Catholic University of Leuven Thibaut HJ , van der Linden L, Jiang P, Thys B, Canela MD, Aguado L, Rombaut B, Wimmer E, Paul A, Pérez-Pérez MJ, van Kuppeveld FJ, Neyts J., Binding of glutathione to enterovirus capsids is essential for virion morphogenesis. PLoS Pathog. 2014 Apr 10;10(4):e1004039. doi: 10.1371/journal.ppat.1004039

The research leading to these results has received funding from the European Community's Seventh Framework Programme [FP7/2007-2013] under grant agreement n° [264286].