Role cellular factors involved in enterovirus replication

EUVIRNA ESR-2

Project description
Enteroviruses are highly prevalent and important human pathogens. This group includes among others, poliovirus (cause of paralytic poliomyelitis), coxsackievirus (major cause of aseptic meningitis and viral myocarditis), human rhinovirus (cause of respiratory tract infections and asthma exacerbations), and enterovirus 71 (cause of large outbreaks in Asia associated with severe neurological sequelae). Thus far, no potent antiviral drugs are available for treatment of enterovirus infections. The development of antiviral drugs against these viruses requires a detailed understanding of the molecular mechanisms of virus replication and the identification of cellular proteins and pathways that are hijacked by the these viruses for efficient replication.

Recently, we have identified a number of new cellular factors / pathways that are essential for the replication of coxsackievirus through a genome-wide RNAi screen. In this project, the role of these proteins / pathways will be investigated in detail to identify their role in the viral life cycle (e.g. do they play a role in entry, translation, replication, or encapsidation; which viral proteins interact with these cellular factors / pathways; etc.).

Host institute
Utrecht University, Utrecht, The Netherlands
Department of Infectious Diseases & Immunology, division of Virology
Supervisor: Prof. dr. Frank van Kuppeveld

The department of Infectious Diseases & Immunology, division of Virology, studies the molecular and cellular aspects of replication of (+)RNA viruses (such as enterovirus and Dengue virus) and aims to find and characterize new inhibitors of virus replication.

Position filled